Influence of azoxymer bromide on the cellular composition of the spleen in experimental infection of T. spiralis

The experiment used white mice, which were divided into 4 groups. first group of mice was injected with a saline solution 0.04 mg Trichinella antigen obtained by the Magat method subcutaneously, second azoxymer bromide (polyoxidonium) at dose 0.004 mg/mouse, third infected larvae without preliminary administration drugs, served as control. A week after last injection invasive 40 larvae/animal. Evaluation protective properties polyoxidonium in laboratory models carried out determining intensity invasion studies all muscle groups animal peptolysis and histological material to assess cellular composition spleen. effectiveness 99.43%. rearrangement structure spleen under influence an immunostimulant indicated high degree reactivity animals response introduction (the ratio red pulp their changes).